Reply: Concentric demyelination pattern in COVID-19-associated acute haemorrhagic leukoencephalitis: a lurking catastrophe?

We are grateful toKarapanayiotides and colleagues (2020) for their description of a 57-year-old patient with acute haemorrhagic leukoencephalitis (AHLE) and concentric demyelination suggestive of Bal ó’s disease, and for adding insights into the neurological manifestations of COVID-19. The authors are correct to point out that the mechanisms underpinning the features in all of our collective patients remain to be determined, and the role of direct infection, hypoxia, immune-mediated injury an d metabolic processes all warrant further exploration. The authors are also correct in describing the difficulty in applying historical terminology to the clinical pictures that we are now seeing in COVID-19, and that new terminologies need to be considered.
Source: Brain - Category: Neurology Source Type: research