Single-cell insights into the hematopoietic generation of T lymphocyte precursors in mouse and man

T and B lymphocyte developmental processes have enjoyed particularly in-depth characterization [1-6]. However, relatively little knowledge concerning T cells has been integrated into current discussions of broader hematopoietic differentiation. Most single-cell transcriptome analyses of multilineage hematopoietic stem and progenitor cells, while powerful and sophisticated [7-12], have under-characterized lymphoid precursors. Cells starting the B cell and natural killer (NK) cell programs are detected in bone marrow and are often labeled as general “lymphoid” precursors [13-15], but benchmarks for initiation of the T-cell program have been lacking.

Source: Experimental Hematology - January 13, 2021 Category: Hematology Authors: Ellen V. Rothenberg Source Type: research