Effect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation: a systematic review and meta-analysis of randomized controlled trials.

EFFECT OF ULTRA-SHORT-ACTING β-BLOCKERS ON MORTALITY IN PATIENTS WITH PERSISTENT TACHYCARDIA DESPITE INITIAL RESUSCITATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Chest. 2021 Jan 09;: Authors: Hasegawa D, Sato R, Prasitlumkum N, Nishida K, Takahashi K, Yatabe T, Nishida O Abstract BACKGROUND: Historically, β-blockers have been considered to be relatively contraindicated for septic shock because they may cause cardiac suppression. On the other hand, there is an increasing interest in the use of β-blockers for treating septic patients with persistent tachycardia despite initial resuscitation. RESEARCH QUESTION: Do ultra-short-acting β-blockers such as esmolol and landiolol improve mortality in septic patients with persistent tachycardia despite initial resuscitation? STUDY DESIGN AND METHODS: This was a systematic review and meta-analysis. We searched MEDLINE, Cochrane Central Register of Controlled Trials, and Embase for RCTs that compared the mortality of patients with sepsis and septic shock treated with esmolol or landiolol. We updated our search on April 20, 2020. Two independent reviewers assessed whether titles and abstracts met the following eligibility criteria: (1) RCT, (2) patients with sepsis and septic shock aged ≥18 years, and (3) treatment with either esmolol/landiolol or placebo/no interventions. Two authors independently extracted selected patient and study characte...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research