Epidemiology, Risk Factors and Outcomes of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation.

Epidemiology, Risk Factors and Outcomes of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation. Chest. 2021 Jan 09;: Authors: Zhang Z, Wang C, Peters SG, Hogan WJ, Hashmi SK, Litzow MR, Patnaik MS, Niven AS, Yadav H Abstract BACKGROUND: Diffuse alveolar hemorrhage (DAH) is an uncommon complication of hematopoietic stem cell transplant (HCT) that carries high morbidity and mortality. There are limited contemporary data regarding the incidence, outcomes and risk factors for DAH. RESEARCH QUESTION: What are the incidence, outcomes, and risk factors for developing DAH after HCT? METHODS: This is a single-center retrospective cohort study of patients who underwent HCT between January 1, 2005 and December 31st, 2016. The incidence and outcomes of DAH development were evaluated. A multivariable logical regression model was used to analyze differences between survivors and non-survivors. RESULTS: Of 4350 patients undergoing first-time HCT, DAH was diagnosed in 99 (2.3%). DAH was seen in 40 of 3536 autologous HCT recipients (1.1 %) and 59 of 814 allogeneic HCT recipients (7.2 %). Mean age was 53 ± 13 years and median time of DAH diagnosis was 126 days (interquartile range: 19-349) post-HCT. In-hospital mortality and mortality one year after DAH diagnosis were 55.6% and 76.8% respectively. DAH diagnosis more than 30 days after transplant (OR: 7.06, 95% CI: 1.65-30.14), low platelet count (OR: 0.98...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research