500K in U.S. diagnosed with Lyme disease annually, but some may not have it
Roughly 500,000 people across the United States are diagnosed with Lyme disease each year, according to new estimates released Wednesday by the CDC, but researchers raise concern that some people may be misdiagnosed.
Conditions: Post Treatment Lyme Syndrome; Chronic Pain; Central Sensitization Interventions: Drug: Milnacipran with D-cycloserine augmentation; Drug: Milnacipran with placebo augmentation Sponsor: Research Foundation for Mental Hygiene, Inc. Terminated
Teaching point: Meticulous anamnesis and a high index of suspicion is needed for the diagnosis of Lyme arthritis. Published on 2021-09-21 11:30:32
Emerg Infect Dis. 2021 Oct;27(10):2715-2717. doi: 10.3201/eid2710.210903.ABSTRACTSurveys indicate US residents spent more time outdoors in 2020 than in 2019, but fewer tick bite-related emergency department visits and Lyme disease laboratory tests were reported. Despite ongoing exposure, Lyme disease case reporting for 2020 might be artificially reduced due to coronavirus disease-associated changes in healthcare-seeking behavior.PMID:34545801 | DOI:10.3201/eid2710.210903
The objective of this study was to estimate the speed and direction of human Lyme disease emergence in Québec and to identify spatiotemporal risk patterns. A surface trend analysis was conducted to estimate the speed and direction of its emergence based upon the first detected case of Lyme disease in each municipality in Québec since 2004. A cluster analysis was also conducted to identify at-risk regions across space and time. These analyses were reproduced for the date of disease onset and date of notification for each case of Lyme disease. It was estimated that Lyme disease is spreading northward in Qu&eacu...
Conditions: Lyme Disease; Healthy Intervention: Diagnostic Test: Lyme diagnostic assay Sponsor: DiaSorin Inc. Enrolling by invitation
AbstractFor diagnosis of neuroborreliosis, calculation of the antibody index, based on Euroimmun Anti-Borrelia plus VlsE ELISA was compared to Virotech Borrelia Europe plus TpN17 immunoblot-based detection ofBorrelia-specific intrathecal antibody production. CXCL13 results in cerebrospinal fluid were used to evaluate discordant results. A total of 64 serum/CSF pairs were analysed. Patients were classified according to European Federation of Neurological Societies criteria incorporating Virotech results. For the Euroimmun assay, a sensitivity of 100% and specificity of 94% was found. Agreement between the both tests was alm...
CONCLUSION: The majority of the cases involved meningoradiculitis but other, less common, neurological conditions have been described. The clinical signs suggestive of meningitis are not very marked and might delay the diagnosis.PMID:34509348 | DOI:10.1016/j.arcped.2021.08.001
by Howard S. Ginsberg, Graham J. Hickling, Russell L. Burke, Nicholas H. Ogden, Lorenza Beati, Roger A. LeBrun, Isis M. Arsnoe, Richard Gerhold, Seungeun Han, Kaetlyn Jackson, Lauren Maestas, Teresa Moody, Genevieve Pang, Breann Ross, Eric L. Rulison, Jean I. Tsao