Therapeutic potential of ATP-sensitive potassium channels in Parkinson's disease.

Therapeutic potential of ATP-sensitive potassium channels in Parkinson's disease.
Brain Res Bull. 2021 Jan 09;:
Authors: Zhao S, Wang M, Ma Z
Abstract
In the past decade, there was an increasing interest in the therapeutic potential targeting ATP-sensitive potassium (KATP) channels for an effective treatment of Parkinson's disease (PD). KATP channels are widely expressed in the central nervous system and were reported to mediate the degeneration and death of nigral dopamine neurons in the pathogenesis of PD. This review aims to address the pivotal roles of KATP channels played in the mechanisms underlying PD pathogenesis, and provide possible directions for further research from different perspectives, such as the vulnerability of dopamine neurons in the substantia nigra, neurotransmitter releasing, iron metabolism in the brain, α-synuclein secretion and mitochondrial dysfunction, which are off critical importance in the investigation of KATP channels-targeted precise therapeutic interventions for PD.
PMID: 33434622 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - January 9, 2021 Category: Neurology Authors: Zhao S, Wang M, Ma Z Tags: Brain Res Bull Source Type: research