Validation of CT radiomics for prediction of distant metastasis after surgical resection in patients with clear cell renal cell carcinoma: exploring the underlying signaling pathways

ConclusionsCT radiomics features can predict distant metastasis after surgical resection of localized ccRCC while the predictive radiomics phenotypes may be driven by key biological pathways related to cancer progression and metastasis.Key Points• Radiomics features from primary tumor in preoperative CT predicted distant metastasis after surgical resection in patients with localized ccRCC.• CT radiomics features predictive of distant metastasis were associated with key signaling pathways related to tumor progression and metastasis.• Gene signature associated with radiomics metastasis score predicted distant metastasis in localized ccRCC.
Source: European Radiology - Category: Radiology Source Type: research