Oncologic significance of unexpected osseous foci on FDG-PET without correlative CT abnormalities

ConclusionOsseous FWCT frequently represent early stages of malignancy. A higher index of suspicion is warranted for osseous FWCT associated with underlying myeloproliferative neoplasms, breast and lung cancer, and moderate (F/L 1.0 –2.0) or high (F/L >  2.0) uptake intensity. Interpreting physicians encountering these variables can recommend interval follow-up with18F-FDG-PET/CT or correlation with contrast-enhanced MRI or tissue biopsy. In patients with an altered biodistribution of18F-FDG in the bone marrow (e.g., recent chemotherapy cycle), follow-up FDG-PET can be obtained at an appropriate time interval following oncologic treatment.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research