Research Shows Why COVID Pneumonia Is More Deadly
People using these medications for diabetes are at risk of a potentially fatal complication called diabetic ketoacidosis (DKA), and it now appears that risk increases even more if they become sick with COVID-19
ConclusionsDespite a rapid worldwide spread, attack rates have been low in most regions, demonstrating the efficacy of control measures.
(Boston Children's Hospital) Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy. Patients given sitagliptin in addition to insulin had a mortality rate of 18 percent as compared with 37 percent in matched patients receiving only insulin. Led by Paolo Fiorina, MD, PhD, of Boston Children's Hospital, the study involved seven Italian hospitals during the first surge of COVID cases last spring.
A lethal form of pneumonia leading to severe acute respiratory syndrome (SARS-CoV-2) caused by a new coronavirus is a disease detected in December 2019 in the People's Republic of China, in Wuhan (Hubei province). This condition quickly spread to other Chinese provinces and all over the world with currently more than 24 million infected patients with nearly 900,000 deaths affecting 188 countries (1-4). Data presented at the CROI 2020 (Conference on Retroviruses and Opportunistic Infection) held in Boston, Massachusetts last March, showed that the clinical spectrum of pneumonia was mild to moderate cases, 80% ; and 20% seve...
SARS-CoV-2 is transmitted by droplets and likely aerosols. The median incubation period is about 5-6 days (range 1-14 days)1 and the median age at confirmed infection in Germany is 49 years. Typical symptoms include fever, cough, anosmia, ageusia, and pneumonia. The mortality rate of COVID-19 is higher among elderly and among ethnicities other than Caucasians. Furthermore, a markedly higher mortality rate has been observed for several comorbidities including obesity class II (BMI 35 •0-39•9 kg/m2) and III (BMI 40•0+ kg/m2), uncontrolled diabetes mellitus, malignancies in the previous year, severely reduced g...
Conclusion: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes.Pathobiology
ConclusionFavipiravir may be an effective option for the treatment of COVID-19-infected patients with ESRD.
A 65-year-old man was admitted to the intensive care unit (ICU) of Tenon hospital, an University-teaching hospital in Paris, France, for a severe confirmed COVID-19 pneumonia. He had a history of diabetes. In the preceding week, the patient developed fever (39 °C), cough and shortness of breath. A chest computed tomography (CT) scan showed bilateral ground glass opacities with alveolar consolidation (Fig. 1A) predominant in the lung periphery as usually reported in COVID-19 pneumonia (Chung et al.
A novel pneumonia of unknown cause was detected in Wuhan, China, which was later named as Corona Virus Disease 2019 (COVID-19) by the World Health Organization (WHO), and the virus that caused this epidemic was named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) .The outbreak of COVID-19 swept across China has aroused global concerns. As of May 5, 2020, more than 3.6 million COVID-19 cases have been confirmed around the world. According to different retrospective studies, among the patients with COVID-19, the case-fatality rate has huge variation [2,3].
CONCLUSION: Patients aged ≥ 70 years, those with fever on admission, and patients with an underlying malignancy or diabetes were found to be more likely to succumb to COVID-19. Elderly in care facilities or hospitalized patients with an underlying disease should receive more attention and be considered for preventive quarantine. PMID: 32924343 [PubMed - in process]
Conclusion: Adrenal insufficiency might be a clinical challenge that needs a prompt treatment also in CS patients during COVID-19 infection. We should consider the possibility to titrate or temporary halt medical therapies of CS in the context of COVID-19 infection. Unexpected hyperkalemia in CS patients under treatment with heparin might be the signal of aldosterone suppression.