Catabolic/anabolic imbalance is accompanied by changes of LV steroid nuclear receptor expression in tachycardia-induced systolic heart failure in male pigsSteroid hormones in pig model of heart failure

: Steroid hormones play an important role in heart failure (HF) pathogenesis, and clinical data has revealed disordered steroidogenesis in male HF patients. However, there is still a lack of studies on steroid hormones and their receptors during HF progression. Therefore, a porcine model of tachycardia-induced cardiomyopathy corresponding to HF was used to assess steroid hormone concentrations in serum and their nuclear receptor levels in heart tissue during the consecutive stages of HF.

Source: Journal of Cardiac Failure - January 12, 2021 Category: Cardiology Authors: Maciej Zacharski, Alicja Tomaszek, Liliana Kiczak, Maciej Ugorski, Jacek Bania, Urszula Pas ławska, Ilona Rybinska, Ewa Anita Jankowska, Adrian Janiszewski, Piotr Ponikowski Source Type: research