LncRNAs and miRNAs participate in determination of response of cancer cells to cisplatin.
LncRNAs and miRNAs participate in determination of response of cancer cells to cisplatin. Exp Mol Pathol. 2021 Jan 07;:104602 Authors: Taheri M, Shoorei H, Anamag FT, Ghafouri-Fard S, Dinger ME Abstract Cisplatin is a widely used chemotherapeutic agent for various types of human malignancies including sarcomas, carcinomas and lymphomas. Yet, the vast application of this drug is hampered by the emergence of chemoresistance in some treated patients. Several mechanisms such as degradation of the membrane transporters by cisplatin have been implicated in the pathogenesis of this event. Recent studies have also indicated the role of long non-coding RNAs (lncRNAs) as well as micoRNAs (miRNAs) in the emergence of resistance to cisplatin in several cancer types. For instance, up-regulation of miR-21 has been associated with resistance to this agent in ovarian cancer, oral squamous cell carcinoma, gastric cancer and non-small cell lung cancer (NSCLC). On the other hand, down-regulation of miR-218 has been implicated in emergence of chemoresistance in breast cancer and esophageal squamous cell carcinoma. MALAT1 is implicated in the chemoresistance of bladder cancer cells, NSCLC, gastric cancer and cervical cancer. Most notably, the expression profile of resistance-associated miRNAs and lncRNAs can predict overall survival of cancer patients. Mechanistic studies have shown that interference with expression of some miRNAs and lncRNAs can reverse the resistance pheno...
Deaths among people who have been fully vaccinated remain rare, but older adults and those with compromised immune systems are at much higher risk.
AbstractSecond-line treatment options for patients with relapsed, extensive-stage small cell lung cancer (ES-SCLC) are limited, and even with currently available treatments, prognosis remains poor. Until recently, topotecan (a topoisomerase I inhibitor) was the only drug approved by the United States (US) Food and Drug Administration (FDA) for the management of ES-SCLC following progression after first-line treatment with etoposide plus a platinum derivative (EP; carboplatin preferred). With the most recent approval of EP plus a prog rammed death ligand 1 (PD-L1) inhibitor, there are now more therapeutic options...
ConclusionThe dermatologist density in Bavaria correlates positively with the incidence of malignant melanoma. Despite an increased incidence, mortality was not elevated in the respective administrative regions.
Colin Powell, the first Black secretary of State and chairman of the Joint Chiefs of Staff, dies of COVID-19 complications after bout with blood cancer.
The WHO lists antimicrobial resistance as a top ten global health threat, saying that by 2050 it will kill more people than cancer. Could novel vaccines provide new ways to defeat superbugs?
Doctors say Colin Powell's age, his battle with multiple myeloma - a type of blood cancer - and Parkinson's contributed to his heightened risk of death from Covid despite being fully vaccinated.
Seattle-based Umoja Biopharma on Monday named Clay Siegall as chairman of its board of directors. Siegall is the CEO and co-founder of Bothell-based Seagen, a biotech company that went public on the Nasdaq in 2001. Siegall co-founded the company in 1998. "Clay's vast scientific training and wealth of experience, particularly his emphasis on targeted cancer therapies and ability to build a com pany from drug discovery to commercial-stage, will be a crucial part of Umoja's continued growth," Andy…
Medicare spent nearly $600 million over a three-year period for cancer care involving four Food and Drug Administration-approved drugs later found to provide no clinical benefit for certain forms of the disease.
Colin Powell had a form of blood cancer that saps natural immunity and also undermines the effects of vaccines like the ones used against Covid-19.
The death of Colin Powell, an 84-year-old former four-star general who served as Chairman of the Joint Chiefs of Staff under U.S. President George H.W. Bush and Secretary of State under President George W. Bush and is perhaps best known for his role in bringing the U.S. into its second war in Iraq, is a high-profile reminder of a grim reality: COVID-19 is not just a pandemic of the unvaccinated, as current president Joe Biden likes to say, but a pandemic of the elderly, too. From early on in the pandemic, we’ve known the virus disproportionately kills older people, and the overall data make that pretty clear: About 5...
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