LncRNAs and miRNAs participate in determination of response of cancer cells to cisplatin.

LncRNAs and miRNAs participate in determination of response of cancer cells to cisplatin. Exp Mol Pathol. 2021 Jan 07;:104602 Authors: Taheri M, Shoorei H, Anamag FT, Ghafouri-Fard S, Dinger ME Abstract Cisplatin is a widely used chemotherapeutic agent for various types of human malignancies including sarcomas, carcinomas and lymphomas. Yet, the vast application of this drug is hampered by the emergence of chemoresistance in some treated patients. Several mechanisms such as degradation of the membrane transporters by cisplatin have been implicated in the pathogenesis of this event. Recent studies have also indicated the role of long non-coding RNAs (lncRNAs) as well as micoRNAs (miRNAs) in the emergence of resistance to cisplatin in several cancer types. For instance, up-regulation of miR-21 has been associated with resistance to this agent in ovarian cancer, oral squamous cell carcinoma, gastric cancer and non-small cell lung cancer (NSCLC). On the other hand, down-regulation of miR-218 has been implicated in emergence of chemoresistance in breast cancer and esophageal squamous cell carcinoma. MALAT1 is implicated in the chemoresistance of bladder cancer cells, NSCLC, gastric cancer and cervical cancer. Most notably, the expression profile of resistance-associated miRNAs and lncRNAs can predict overall survival of cancer patients. Mechanistic studies have shown that interference with expression of some miRNAs and lncRNAs can reverse the resistance pheno...
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research

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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Multiple Myeloma Bone Marrow Deaths (Fatalities) Immune System Blood Powell, Colin L Source Type: news
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