Dynamics of HIV-1 quasispecies diversity of participants under long-term antiretroviral therapy based on intra-host single-nucleotide variations

According to UNAIDS, 23.3 million (62%) people with HIV underwent antiretroviral therapy (ART) in 2018, an increase of 1.6 million from 2017 (UNAIDS, 2019). Currently, the primary and most effective strategy for HIV/AIDS prevention and treatment is combined antiretroviral therapy, and, in particular, the first-line antiretroviral drugs are the most widely used regimens (Kanters et al., 2016). Although ART has led to substantial gains in the reduction of mortality and morbidity of HIV/AIDS, the abundant genetic diversity and rapid variation, making it impossible to completely eradicate the virus in participants (Deeks et al., 2013).

Source: International Journal of Infectious Diseases - January 11, 2021 Category: Infectious Diseases Authors: Yuanyuan Zhang, Qianqian Yin, Ming Ni, Tingting Liu, Chen Wang, Chuan Song, Lingjie Liao, Hui Xing, Shibo Jiang, Yiming Shao, Chen Chen, Liying Ma Source Type: research