Improving Translational Research Outcomes for Opioid Use Disorder Treatments
AbstractPurpose of ReviewPharmacotherapies are the most effective means of reducing the harms associated with opioid use disorder (OUD). Translational research seeking to develop novel medications to treat OUD has been challenging due to the complex etiology of addiction. Preclinical outcome measures are often behavioral, and it is difficult, if not impossible, to fully mirror the various emotional and cognitive processes that motivate opioid use in humans. The goal of the current narrative review was to summarize the translational progression of three potential medications for OUD, which had varying levels of success.Recent FindingsMemantine, lorcaserin, and lofexidine all showed promise in preclinical studies; however, only lofexidine was able to consistently replicate these findings in human subjects, and receive FDA approval. It was the authors ’ objective to use this review to identify areas of needed improvement in translational research for OUD.SummaryPreclinical studies vary significantly in their ability to forecast effectiveness in clinical trials. Among the various preclinical models, suppression of opioid self-administration appears to have the best predictive validity. As they model a mostly physiological phenomenon, preclinical assessments of opioid withdrawal also appear to have high predictive validity. In our review of the literature, the authors noted numerous examples of clinical trials that were underpowered, lack precision, and proper outcomes. Bett...
This study evaluates what factors increase postoperative opioid prescriptions in children at our institution.
In my previous article, I highlighted some of the most interesting insights and perspectives from the start of HLTH 2021 along with some of the culture of the conference. Plus, hopefully you got a chance to read Colin Hung’s article about Health Equity at HLTH 2021. Now I’m going to share a number of products, […]
Condition: Addiction Interventions: Other: 1-WHOQOL-BREF(WHO-Quality of life-BREFF) Arabic version Scale; Other: SCL-90-R(Symptoms Checklist-90-Revised) Arabic version scale; Other: addiction severity index Sponsor: Assiut University Not yet recruiting
Patients taking or coming off addictive medication should be offered regular reviews by their GP, nurse or pharmacist, draft guidance from NICE warns.
Buprenorphine misuse in those with opioid use disorder has dropped, but new data also show 50% of patients aren't receiving addiction treatment and may be misusing the drug in an effort to self-treat.Medscape Medical News
This study aimed to identify the variables (i.e., internalizing, and externalizing problems, self-control, emotion dysregulation, and alexithymia) relevant for Smartphone Addiction and non-suicidal self-injury (NSSI), conceptualized as emotion-regulation s...
Nov 3, 2021. . Sponsored by University of Vermont Center on Rural Addiction
WorkIt Health cofounders Robin McIntosh and Lisa McLaughlin want to help the 9 in 10 Americans with a substance use disorder who have avoided treatment due to access or affordability or stigma.
This study examined two key occupational groups within the AOD workforce: nurses and counsellors. Cross-sectional data from an Australian online survey of the AOD workforce was analysed to identify the socio-demographic and organisational factors that predicted job satisfaction and turnover intentions. Around half of nurses and counsellors were satisfied with their jobs, with the majority satisfied with the AOD sector. For both groups, job and sector satisfaction were positively associated with feeling respected and supported and working in an environment open to change. Satisfaction was the strongest predictor of job and ...