Total Phenolic Fraction (TPF) from Extra Virgin Olive Oil: Induction of apoptotic-like cell death in < i > Leishmania < /i > spp. promastigotes and < i > in vivo < /i > potential of therapeutic immunomodulation

Conclusions/SignificanceTPF exhibits chemotherapeutic anti-leishmanial activity by inducing programmed cell death on cell-free promastigotes and immunomodulatory properties that inducein vivo T cell-mediated responses towards the protective Th1 response in experimental cutaneous leishmaniasis. These findings enable deeper understanding of TPF ’s dual mode of action that encourages further studies.

Source: PLoS Neglected Tropical Diseases - January 11, 2021 Category: Tropical Medicine Authors: Kalliopi Karampetsou Source Type: research