Elf4 regulates lysosomal biogenesis and the mTOR pathway to promote clearance of Staphylococcus aureus in macrophages

AbstractStaphylococcus aureus (S. aureus) is a major cause of infectious disease. Macrophages can directly destroy most of the invading bacteria through the phagolysosomal pathway. E74 ‐like factor 4 (Elf4) is one of the important transcription factors that controls diverse pathogens, but the role of Elf4 in macrophage‐mediatedS. aureus eradication is unknown. Our data show that Elf4 is induced byS. aureus in macrophages. Elevated expression of Elf4 results in decreased bacterial load and inflammatory responses duringS. aureus infectionin vivo andin vitro. Elf4 ‐overexpressed macrophages have decreased mTOR activity and increased lysosomal mass. Collectively, these results suggest thatS. aureus induces Elf4 expression, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH ARTICLES Source Type: research