mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry

“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. “Probably not,” she answered, “but we want to be careful. This is very important to get right.” I became a vaccine guinea pig because, in addition to wanting to be useful, I had a deep interest in the wondrous new roles now being played by RNA, the genetic material that is at the heart of new types of vaccines, cancer treatments and gene-editing tools. I was writing a book on the Berkeley biochemist Jennifer Doudna. She was a pioneer in determining the structure of RNA, which helped her and her doctoral adviser figure out how it could be the origin of all life on this planet. Then she and a colleague invented an RNA-guided gene-editing tool, which won them the 2020 Nobel Prize in Chemistry. The tool is based on a system that bacteria use to fight viruses. Bacteria develop clustered repeated sequences in their DNA, known as CRISPRs, th...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized COVID-19 feature Magazine Source Type: news

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A lot of questions about the Pfizer/BioNTech booster shots are circulating after decisions from the FDA and the CDC and recommendations from two vaccine advisory committees.Medscape Medical News
Source: Medscape Pharmacist Headlines - Category: Drugs & Pharmacology Tags: Infectious Diseases News Source Type: news
PlastCare Offers FDA Approved Dental Supplies on bttn. PlatformSEATTLE, Sept. 21, 2021 /PRNewswire/ -- bttn., a HealthTech startup providing a B2B e-commerce platform for purchasing medical supplies, today announced a massive expansion to its product catalog with the addition of 93 PlastCare USA products for dental practitioners. bttn. has seen a dramatic increase in the number of dental practices utilizing its medical supply platform in recent months. The addition of the PlastCare catalog fleshes out bttn.'s dental supply offerings and brings 23 new dental product categories to customers of the rapidly grow...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
During National Suicide Prevention Awareness Month, NIMH hosted a livestream event on suicide prevention during the pandemic, focusing on unemployment, youth, and other population subgroups who may be experiencing elevated risk.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
A low number of children have contracted Covid-19 in Oregon compared with other states, according to Oregon Health&Science University ’s latest forecast. Only seven states have lower pediatric census rates than Oregon, where 0.70 per 100,000 of those under the age of 18 are hospitalized for Covid, according to the report, from Peter Graven, lead data scientist in OHSU’s Business Intelligence unit. Graven said that the data s uggest that children are protected when the adults around them are…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
A relatively small number of children in Oregon have contracted the virus compared to other states.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dalton Trans., 2021, Advance Article DOI: 10.1039/D1DT01460A, PaperLiping Qiao, Jiangping Liu, Shi Kuang, Xinxing Liao, Junfeng Kou, Liangnian Ji, Hui Chao A mitochondria-targetedBODIPY-Ir(III) conjugate acted as a photoinduced ROS generator and exerted high oxidative lethality towards triple-negative breast cancer cells at an ultralow concentration under irradiation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
While the Covid-19 vaccines were developed far from Pittsburgh, a lab at Carnegie Mellon University is making advances in the delivery of the same type of messenger RNA technology that made the first vaccines possible to battle other diseases. The second day of the Precision Medicine World Conference, held in downtown Pittsburgh, began with examples of how the Covid-19 pandemic had changed the region and the world — and BioNTech founders Ugur Sahin and Ozlem Tureci and a leading mRNA researcher…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Magazine Source Type: news
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