A rat toxicological study of intra-arterial injection of Tirapazamine, a hypoxia-activating Cancer therapeutic agent, followed by hepatic artery ligation

Conclusion TPZ by IA injection followed by embolization is tolerated up to 7  mg/kg. This finding supports the strategy of administering an IA injection of TPZ followed by trans-arterial embolization to the liver.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research