Topological analysis for sequence variability: Case study on more than 2K SARS-CoV-2 sequences of COVID-19 infected 54 countriesvin comparison with SARS-CoV-1 and MERS-CoV.

Topological analysis for sequence variability: Case study on more than 2K SARS-CoV-2 sequences of COVID-19 infected 54 countriesvin comparison with SARS-CoV-1 and MERS-CoV. Infect Genet Evol. 2021 Jan 06;:104708 Authors: Sarkar JP, Saha I, Seal A, Maity D, Maulik U Abstract The pandemic due to novel coronavirus, SARS-CoV-2 is a serious global concern now. More than thousand new COVID-19 infections are getting reported daily for this virus across the globe. Thus, the medical research communities are trying to find the remedy to restrict the spreading of this virus, while the vaccine development work is still under research in parallel. In such critical situation, not only the medical research community, but also the scientists in different fields like microbiology, pharmacy, bioinformatics and data science are also sharing effort to accelerate the process of vaccine development, virus prediction, forecasting the transmissible probability and reproduction cases of virus for social awareness. With the similar context, in this article, we have studied sequence variability of the virus primarily focusing on three aspects: (a) sequence variability among SARS-CoV-1, MERS-CoV and SARS-CoV-2 in human host, which are in the same coronavirus family, (b) sequence variability of SARS-CoV-2 in human host for 54 different countries and (c) sequence variability between coronavirus family and country specific SARS-CoV-2 sequences in human host. For t...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research