Erythroid Enucleation: A gateway into a "bloody" world

Erythrocytes or red blood cells (RBCs) constitute by large the predominant component of blood. RBCs are devoid of nucleus and other organelles, lack the cellular machinery needed for transcription and translation and contain mainly hemoglobin that binds and transports oxygen throughout the body. In humans, RBCs have a life span of ∼120 days [1] [variable in mice depending on the strains, 22 days in C57BL/6 mice], and are eventually cleared by macrophages. As a result, RBCs are constantly replenished from hematopoietic stem and progenitor cell differentiation.

Source: Experimental Hematology - January 10, 2021 Category: Hematology Authors: Vijay Menon, Saghi Ghaffari Source Type: research