Epigenetics in atrial fibrillation: a reappraisal

Atrial fibrillation (AF) is the most common cardiac arrhythmia and an important cause of morbidity and mortality globally. Atrial remodeling includes changes in ion channel expression and function, structural alterations, and neural remodeling, which create an arrhythmogenic milieu resulting in AF initiation and maintenance. Current therapeutic strategies for AF involving ablation and antiarrhythmic drugs are associated with a relatively high recurrence and pro-arrhythmic side effects respectively.

Source: Heart Rhythm - January 10, 2021 Category: Cardiology Authors: Rosa Do ñate Puertas, Rishi Arora, Sophie Rome, Babken Asatryan, H. Llewelyn Roderick, Philippe Chevalier Source Type: research