GM-CSF instigates a dendritic cell - T cell inflammatory circuit that drives chronic asthma development

Neutrophils are associated with severe chronic disease in asthma and GM-CSF is required for their accumulation in the inflamed lung by promoting lung dendritic cell dependent induction of Th2/Th17 cell immunity

Source: Journal of Allergy and Clinical Immunology - January 10, 2021 Category: Allergy & Immunology Authors: Samuel Philip Nobs, Lea Pohlmeier, Fengqi Li, Merve Kayhan, Burkhard Becher, Manfred Kopf Source Type: research