Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology

ConclusionsOur data provide insights into the structural basis of hGDH2 properties, the functional evolution of hGDH isoenzymes, and open new prospects for drug design, especially for cancer therapeutics.

Source: Journal of Neurochemistry - January 9, 2021 Category: Neuroscience Authors: Christina Dimovasili, Vasiliki E. Fadouloglou, Aikaterini Kefala, Mary Providaki, Dina Kotsifaki, Konstantinos Kanavouras, Iosifina Sarrou, Andreas Plaitakis, Ioannis Zaganas, Michael Kokkinidis Tags: ORIGINAL ARTICLE Source Type: research