Anti- β2-glycoprotein I and anti-prothrombin antibodies cause lupus anticoagulant through different mechanisms of action.

CONCLUSION: Anti-β2GPI and anti-prothrombin antibodies cause LA through different mechanisms of action: while anti-β2GPI antibodies interfere with FV activation by FXa through a direct interaction with FV, anti-prothrombin antibodies compete with FXa for phospholipid binding sites. These data provide leads for understanding the paradoxical association between thrombosis and a prolonged clotting time in the antiphospholipid syndrome.
PMID: 33421291 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Noordermeer T, Molhoek JE, Schutgens REG, Sebastian SAE, Drost-Verhoef S, van Wesel ACW, de Groot PG, Meijers JCM, Urbanus RT Tags: J Thromb Haemost Source Type: research