Follicular lymphoma-associated BTK mutations are inactivating resulting in augmented AKT activation.

CONCLUSIONS: Altogether, our data uncover novel unexpected properties of FL-associated BTK mutations with direct implications for targeted therapy development in FL.
PMID: 33419778 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 8, 2021 Category: Cancer & Oncology Authors: Malek S, Hu N, Wang F, Sun T, Xu Z, Zhang J, Bernard D, Xu S, Wang S, Kaminski MS, Devata S, Phillips T Tags: Clin Cancer Res Source Type: research