Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation.

Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation.
Cell Stem Cell. 2021 Jan 07;28(1):3-5
Authors: Ballard EB, Wu J
Abstract
Blastocyst complementation represents a powerful technique for interspecies organogenesis but is limited by low chimerism due to developmental incompatibilities. In this issue of Cell Stem Cell,Nishimura et al. (2021) circumvent early developmental barriers by disabling Igf1r in host embryos, conferring donor cells with a growth advantage from mid-gestation onward.
PMID: 33417870 [PubMed - as supplied by publisher]

Source: Cell Stem Cell - January 7, 2021 Category: Stem Cells Authors: Ballard EB, Wu J Tags: Cell Stem Cell Source Type: research