An integrated mathematical model of the cardiovascular and respiratory response to exercise: Model-building and comparison with reported models.

An integrated mathematical model of the cardiovascular and respiratory response to exercise: Model-building and comparison with reported models. Am J Physiol Heart Circ Physiol. 2021 Jan 08;: Authors: Sarmiento CA, Hernandez AM, Serna Higuita LY, Mañanas MÁ Abstract The use of physiological models in medicine allows the evaluation of new hypotheses, development of diagnosis and clinical treatment applications, development of training and medical education tools, as well as medical device design. Although several mathematical models of physiological systems have been presented in the literature, few of them are able to predict the human cardiorespiratory response under physical exercise stimulus adequately. This paper aims to present the building and comparison of an integrated cardiorespiratory model focused on the prediction of the healthy human response under rest and aerobic exercise. The model comprises cardiovascular circulation, respiratory mechanics, gas exchange system, as well as cardiovascular and respiratory controllers. Every system is based on previously reported physiological models and incorporates reported mechanisms related to the aerobic exercise dynamics. Experimental data of thirty healthy male volunteers undergoing a cardiopulmonary exercise test and simulated data from two of the most current and complete cardiorespiratory models were used to evaluate the performance of the presented model. Experimental design...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research