New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans.

In conclusion, cardiac SGLT1 does not contribute to overall glucose uptake, probably due to the expression of slc5a1 transcript variant. The inhibitory effect of phlorizin on cardiac glucose uptake is SGLT1-independent and can be explained by GLUT transporter inhibition. These data open new perspectives in understanding the role of SGLT1 in the heart. PMID: 33416451 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33416451?dopt=Abstract

Source: American Journal of Physiology. Heart and Circulatory Physiology - January 8, 2021 Category: Physiology Authors: Ferté L, Marino A, Battault S, Bultot L, Van Steenbergen A, Bol A, Cumps J, Ginion A, Koepsell H, Dumoutier L, Hue L, Horman S, Bertrand L, Beauloye C Tags: Am J Physiol Heart Circ Physiol Source Type: research