Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.

CONCLUSIONS: Endothelial Nox4 dysfunction upregulated sEH to enhance inflammation, probably by its induction of ER stress. Inhibition of ER stress or sEH is beneficial to alleviate atherosclerosis caused by endothelial Nox4 dysfunction.
PMID: 33418110 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - January 5, 2021 Category: Biology Authors: Yu W, Li S, Wu H, Hu P, Chen L, Zeng C, Tong X Tags: Free Radic Biol Med Source Type: research