Preliminary adipose removal did not prevent diet-induced metabolic disorders in mice.

CONCLUSIONS: Our data suggest that removal of epididymal adipose or subcutaneous adipose alone or in combination before the onset of obesity did not protect against hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in LDL-R KO mice fed with a HFD. Hence, adipose removal possibly does not represent a potential approach in preventing obesity-related metabolic disorders in the obesity-susceptible population.
PMID: 33410621 [PubMed - as supplied by publisher]

Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Liu L, Liang CX, Wang XW, Pei KX, Ma XD, Zhang CX, Dong JH, Gao MM, Liao JW Tags: Chin Med J (Engl) Source Type: research