The complex relationship between C4b Binding Protein, warfarin and antiphospholipid antibodies.

Conclusion: Both antiphospholipid antibodies and warfarin are associated with C4BPt reduction. Complement activation in aPL ++ patients may partly be explained by impaired inhibition through depressed C4BPt levels. Further studies are needed to understand the clinical implication.
PMID: 33412597 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Grosso G, Sandholm K, Antovic AM, Gunnarsson I, Zickert A, Vikerfors A, Truedsson L, Bruzelius M, Nilsson B, Nilsson Ekdahl K, Svenungsson E Tags: Thromb Haemost Source Type: research