Commonly used antibiotics with diuretic can double risk of sudden death in older patients

The combination of the commonly prescribed antibiotic trimethoprim-sulfamethoxazole with the diuretic spironolactone, widely used for heart failure, more than doubles the risk of death for older patients, reports a study.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSION: discharge planning based on the NIC improves the NOC score and may interfere in the health outcomes. PMID: 32609201 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
Abstract In recent years, home medical care has been strongly promoted. As a consequence, the conditions managed in home medical care have become increasingly diverse. Heart failure is one of the most common disorders after malignant diseases. Patients with chronic heart failure (CHF) are often forced into hospitalization because of the inability to control symptoms with oral medications, even though they hope to stay at home. Recently, we have experienced a case where the patient required continuous administration of dobutamine at home. In order to carry out CHF care at home successfully, it is necessary to adjus...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Conclusion: Our results showed a lack of association between serum levels of IL-33 and sST2 and HF. Moreover, the results do not confirm the cardioprotective mechanism of carvedilol by means of IL-33/sST2 pathway. PMID: 32607003 [PubMed]
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
Conclusions: This study is the first to identify that Serelaxin increases the expression of its own receptor RXFP1 and that this mediates the inhibition of EndMT and cardiac fibrosis, suggesting that Serelaxin may have a beneficial effect as anti-fibrotic therapy in chronic heart failure.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
REV-ERBα (NR1D1) is a circadian clock component that functions as a transcriptional repressor. Due to its role in direct modulation of metabolic genes, REV-ERBα is regarded as an integrator of cell metabolism with circadian clock. Accordingly, REV-ERBα is first proposed as a drug target for treating sleep disorders and metabolic syndromes (e.g., dyslipidaemia, hyperglycaemia and obesity). Recent years of studies uncover a rather broad role of REV-ERBα in pathological conditions including local inflammatory diseases, heart failure and cancers. Moreover, REV-ERBα is involved in regulation of cir...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Conclusions: Collectively, serum LL-37 is associated with acute HF and increasing CRAMP is protective against deleterious NF-κB signaling in the rodent.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Acute heart failure is the rapid onset of signs and symptoms of heart failure and is commonly precipitated by cardiac ischemia and uncontrolled hypertension.1 Sigmoid volvulus is the twisting of the sigmoid colon around itself and its mesentery.2 This case highlights the important association of elevated intra-abdominal pressure and heart failure.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Publication date: Available online 2 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Elif Hande Ozcan Cetin, Mehmet Serkan Cetin, Mustafa Bilal Özbay, Nezaket Merve Yaman, Hasan Can Könte, Firdevs Aysenur Ekizler, Bahar Tekin Tak, Meryem Kara, Ahmet Temizhan, Fırat Özcan, Özcan Özeke, Serkan Çay, Serkan Topaloglu, Dursun Aras
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Cell and tissue biology always turns out to be more complicated than we would all prefer. Present understanding is rarely complete to the point at which all obstacles are known. It is one of the reasons why the development of new classes of medical therapy is a challenging business. Consider the topic of autophagy in aging, for example. Autophagy is the name given to a collection of processes responsible for recycling unwanted and damaged molecules and structures in the cell. Material is conveyed, in one way or another depending on the type of autophagy, to a lysosome and engulfed. Lysosomes are membrane-bound packages of ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
CONCLUSIONS: While PREDICT-CVD equations performed better than PCEs, neither performed well. Multimorbidity and competing risks are likely to contribute to the poor performance and new CVD risk equations need to include these factors. PMID: 32595220 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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