Commonly used antibiotics with diuretic can double risk of sudden death in older patients
The combination of the commonly prescribed antibiotic trimethoprim-sulfamethoxazole with the diuretic spironolactone, widely used for heart failure, more than doubles the risk of death for older patients, reports a study.
Publication date: Available online 19 June 2019Source: Biosensors and BioelectronicsAuthor(s): Jialin Zhao, Danli Liang, Shouwei Gao, Xiaojun Hu, Kwangnak Koh, Hongxia ChenAbstractB-type natriuretic peptide (BNP) is a short peptide that is considered to be an important heart failure (HF)-related biomarker. Due to its low concentration in the blood and short half-life, the sensitive detection of BNP is a bottleneck for diagnosing patients at early stages of HF. In this paper, we report a facile surface plasmon resonance (SPR) sensor to measure BNP; the sensor is based on aptamer-functionalized Au nanoparticles (GNPs-Apt) an...
ConclusionsThe results suggest that the method can achieve accurate generalizable models for automated diagnosis of CHF from short-term HRV segments in subjects with very few informative features. The choice of the best features and the classification results are similar between the three best classifiers, so the use of any of them with the proposed method is recommended. Nonlinear and symbolic dynamics features are shown to have an important role in the resulting models. The presented methodology may be useful for first-hand screening for CHF as well as for similar diagnostic or automated detection problems in biomedicine.Graphical abstract
ConclusionThe nature of patients’ knowledge of HF is both explicit and implicit, dynamic, and personal. This multidimensional model of knowledge-in-context calls for equally multidimensional research and intervention design.
Regular consultations with pharmacists lead to improved medicine adherence in people with chronic heart failure (HF), research results show.
Tina Esposito, chief health information officer at Advocate Aurora Health, says her organization's data and analytics heart failure pilot realized a 23 percent reduction in utilization.
A significant subset of patients with heart failure (HF) experience small to moderate rise in serum creatinine (RSC) in the setting of otherwise beneficial therapies such as aggressive diuresis or renin-angiotensin-aldosterone system (RAAS) inhibition. Accumulating data suggest that RSC in this setting is dissimilar from conventional causes of renal insult in that it has a negligible impact on the outcomes. There is also emerging evidence on the lack of association between biomarkers of renal injury and RSC in the setting of aggressive diuresis. A similar pattern has been observed in recent hypertension trials where the RS...
Publication date: Available online 18 June 2019Source: Journal of the Saudi Heart AssociationAuthor(s): Jakrin Kewcharoen, Narut Prasitlumkum, Chanavuth Kanitsoraphan, Nattawat Charoenpoonsiri, Natthapon Angsubhakorn, Prapaipan Putthapiban, Pattara Rattanawong
ConclusionSpironolactone does not reduce the risk of new-onset AF or AF recurrence in patients with HFpEF. This is in contrast to results in cohorts of patients with HF and a reduced ejection fraction.Clinical trial registrationClinicalTrials.gov identifier no. NCT00094302 (TOPCAT).
AbstractThis meta-analysis was conducted to investigate whether heart failure is associated with an increased risk of fractures by summarizing all the available evidence. The PubMed, EMBASE, and Cochrane Library databases were searched for all relevant studies published from the date of database inception to April 2018. Studies that investigated the association between heart failure and fracture risk and conducted a comparison with controls were included. Seven cohort studies were finally identified as eligible for inclusion in the meta-analysis. All included studies were of high quality as evaluated by the Newcastle-Ottaw...