Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.

Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.
Nat Prod Res. 2021 Jan 06;:1-6
Authors: Zhao YN, Gao G, Ma JL, Xu RZ, Guo T, Wu LM, Liu XG, Xie ZS, Xu JY, Zhang ZQ, Wang P
Abstract
Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.
PMID: 33401972 [PubMed - as supplied by publisher]

Source: Natural Product Research - January 6, 2021 Category: Biochemistry Authors: Zhao YN, Gao G, Ma JL, Xu RZ, Guo T, Wu LM, Liu XG, Xie ZS, Xu JY, Zhang ZQ, Wang P Tags: Nat Prod Res Source Type: research