Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa –induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome

ConclusionsPA infection attenuated macrophage phagocytosis through activation of NLRC4 inflammasome in macrophages, which eventually led to pulmonary inflammatory damage in mouse; ASCs reduced the activation of NLRC4 inflammasome in macrophages induced by PA infection, thereby increasing the phagocytic ability of macrophages, and ultimately improving lung tissue damage in mouse; ASCs may inhibit NLRC4 inflammasome through the secretion of STC-1.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research