Association of hOGG1 ‐Cys variants with occurrence of p53 and EGFR deletion mutations in non‐small cell lung cancer

ConclusionsWe suggest that the association ofhOGG1 Ser326Cys polymorphism with lung cancer risk could be partially explained by increases inp53 andEGFR deletion mutations.Key pointsSignificant findings of the study NSCLC patients withhOGG1‐Cys variants may have a higher risk ofp53 andEGFR deletion mutations than withhOGG1 Ser/Ser genotype.What this study adds NSCLC patients withhOGG1‐Cys variants might be helpful to predict patients having higher risk ofEGFR exon 19 deletion mutations and these patients who were treated with gefitinib or erlotinib could be a higher risk to occurEGFR T790M mutation.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research