Rheumatoid arthritis: Inflammation feeds inflammation—HDAC5 downregulation leads to activation of fibroblast-like synoviocytes in RA

Nature Reviews Rheumatology 11, 64 (2015). doi:10.1038/nrrheum.2014.213 Author: João H. Duarte New research in Annals of the Rheumatic Diseases has revealed that IL-1β and TNF suppress the expression of histone deacetylase 5 (HDAC5) in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA), an effect that leads to an increase in the production of inflammatory
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Tags: Research Highlight Source Type: research