Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2.

Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2.
Nat Prod Res. 2021 Jan 04;:1-7
Authors: Liao Y, Hong X, Yang J, Qin JJ, Zhang B, Lin J, Shao Z, Wang W
Abstract
A novel cyclic tripeptide, sclerotiotide M (1), was isolated from the culture of a marine derived fungus Aspergillus ochraceopetaliformis DSW-2, together with four known compounds (2-5). The planar structure of 1 was established by 1 D and 2 D NMR data, supported by mass spectrometry, and the relative configuration was established by calculated NMR chemical shifts coupled with a statistical method (DP4+). All the compounds (1-5) displayed weak cytotoxic activities against cancer cell lines HPAC and BXPC3, with IC50 values over 20 μM.
PMID: 33397147 [PubMed - as supplied by publisher]

Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Liao Y, Hong X, Yang J, Qin JJ, Zhang B, Lin J, Shao Z, Wang W Tags: Nat Prod Res Source Type: research