Association between interleukin-10 polymorphisms and CD4+CD25+FOXP3+ T cells in asthmatic children.

CONCLUSIONS: Our results suggest that moderate asthma is associated with a higher frequency of the T allele in the SNP rs3024491. In addition, the variant rs3024491 (TT) was associated with a reduction in IL-10 production and an increased percentage of Tregs cells, suggesting possible mechanisms that influence asthma severity. PMID: 33400919 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33400919?dopt=Abstract

Source: Jornal de Pediatria - January 2, 2021 Category: Pediatrics Authors: Mocellin M, de Azeredo Leitão LA, de Araújo PD, Jones MH, Stein RT, Pitrez PM, de Souza APD, Pinto LA Tags: J Pediatr (Rio J) Source Type: research