Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice.

In this study, we evaluated the effect that juzentaihoto hot water extract (JTT) has on skeletal muscle atrophy and motor function by administering it to senescence-accelerated mouse prone-8 (SAMP8). The group treated with JTT displayed larger gastrocnemius muscle (GA) and extensor digitorum longus (EDL) weights, larger GA muscle fiber cross-sectional areas, and motor function decline during rota-rod tests. JTT also increased IGF-1 serum levels, as well as mRNA Sirt1 levels in GA. Serum levels of tumor necrosis factor-α, interleukin-6, and mRNA levels of Atrogin1 and MuRF1 in GA were reduced by JTT. The muscle fiber cross-sectional area of GA was correlated with the mRNA levels of Sirt1 in GA. The results of this study suggested that JTT administration suppresses skeletal muscle atrophy and motor function decline in SAMP8 mice. This effect may be associated with the increased expression levels of Sirt1 and IGF-1 by JTT.
PMID: 33390547 [PubMed - in process]

Source: Biological and Pharmaceutical Bulletin - January 6, 2021 Category: Drugs & Pharmacology Authors: Morita Y, Ishida T, Morisawa S, Jobu K, Ou Y, Fujita H, Hanazaki K, Miyamura M Tags: Biol Pharm Bull Source Type: research