The effect of anabolic-androgenic steroid abuse on the contact activation system.

The effect of anabolic-androgenic steroid abuse on the contact activation system.
Thromb Haemost. 2021 Jan 05;:
Authors: Sidelmann JJ, Gram JB, Palarasah Y, Rasmussen JJ, Kistorp C
Abstract
The effect of anabolic-androgenic steroid (AAS) abuse on the contact activation system (CAS) is not known in detail. We hypothesized that current AAS abuse reduces the kallikrein generating capacity of CAS significantly and investigated the impact of AAS on the proteins and capacity of CAS in current and former AAS abusers and healthy age matched controls. Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers or controls. Blood samples were collected after overnight fasting. Kallikrein generation (lag time, peak height, and endogenous kallikrein potential (EKP)), coagulation factor XII (FXII), prekallikrein, high molecular weight kininogen (HK), and C1 esterase inhibitor (C1inh) were assessed. Groups were compared by ANOVA or Kruskal-Wallis test and probabilities were corrected for multiple comparisons. Associations were evaluated by linear regression models. The EKP was significantly reduced in current (n=37) AAS abusers (984 ± 328 nmol/L x min) compared to former (n=33) abusers (1543 ± 481 nmol/L x min) and controls (n=30) (1521 ± 339 nmol/L x min), p<0.001. Current abusers had higher levels of FXII and C1inh and lower levels of prekallikrein and HK than controls, p ≤ 0.025. Stepwise regression analysis showe...

Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Sidelmann JJ, Gram JB, Palarasah Y, Rasmussen JJ, Kistorp C Tags: Thromb Haemost Source Type: research