Cardiovascular diseases and COVID-19 : Pathophysiology, complications and treatment.

[Cardiovascular diseases and COVID-19 : Pathophysiology, complications and treatment]. Herz. 2021 Jan 04;: Authors: Schieffer E, Schieffer B, Hilfiker-Kleiner D Abstract The coronavirus disease 2019 (COVID-19) pandemic is a challenge for our healthcare system but at the same time is one of the excellent catalyzers and promoters of successful translational research. The COVID-19 is not only a simple viral infection of the bronchial system but is also a pandemic hyperinflammatory multiorgan disease. The cardiovascular system plays a causal role in this context, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells via the angiotensin-converting enzyme 2 (ACE-2), an enzyme in the renin-angiotensin system. Furthermore, cardiovascular comorbidities and risk factors, such as hypertension, diabetes and obesity play an important role in the severity of the course of the disease. Additional risk factors, such as gender, age, genetics and air pollution modulate both the severity of the SARS-CoV‑2 infection as well as cardiovascular diseases. As sequelae of COVID-19, increased thrombosis, myocardial infarction, myocardial inflammation and vasculitis occur, which directly damage the cardiovascular system and substantially contribute to the high morbidity and mortality. Knowledge gained from many studies on the course of the disease in patients infected with SARS-CoV‑2 has led to improved treatment possibilities, which n...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research

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AbstractChronic thromboembolic pulmonary hypertension is an underdiagnosed condition. Patients typically present with the symptoms of right heart failure. Diagnosis is usually done by radionuclide ventilation/perfusion (VQ) scan, high-quality multidetector computed tomography (CT) or pulmonary angiography at expert centers. Pulmonary endarterectomy remains the corner stone in management of chronic thromboembolic pulmonary hypertension. Deep hypothermic circulatory arrest is commonly used for the operation at most centers. In-hospital mortality ranges from 1.7 to 14.2%. Pulmonary hemorrhage, reperfusion lung injury, and rig...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Commenting on the announcement that the government is to end the public sector pay freeze UNISON general secretary Christina McAnea said: “There’s never a good time to freeze public sector pay. Doing so at the peak of a pandemic was the height of folly. “Staff were doing their all to keep under-pressure services running, and ministers looked like they didn’t care. “There can be no decent public services without the people to run them. Pay freezes don’t help employers hold on to experienced staff, nor attract new recruits. “But if the chancellor doesn’t allocate...
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Oct 27, 2021. . Sponsored by Center for Homeland Defense and Security
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This study aims to examine the consequent changes in medical school curricula alongside students’ mental and physical health. It is observed that 549 medical students (response rate: 79.7%) from 31 of 37 public medical schools in Germany completed a cross-sectional online survey. Students answered questions regarding teaching, internet use, COVID-19 and well-being. A multivariate logistic regression examined factors associated with depressed mood, insomnia and headache. Academic teaching moved to a virtual environment (91%), whilst practical activities were suspended or cancelled (88%). Virtual teaching modalit...
Source: The Journal of Mental Health Training, Education and Practice - Category: Psychiatry & Psychology Authors: Source Type: research
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Nov 17, 2021. US. Sponsored by Indiana Rural Health Association
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A major gap exists in the present spectrum of efforts to develop the means to treat aging, rejuvenate the old, and turn back age-related conditions. An the one hand, a small number of promising potential therapies to treat the mechanisms of aging can at present be applied by physicians off-label, or otherwise without the need for a great deal of interaction with the FDA. On the other hand, there are a good hundred or more clinical indications, specific age-related conditions recognized by regulatory authorities, that might be improved by these therapies. Several hundred small, informal trials could be run, starting now, gi...
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