Combining clinical and dosimetric features in a PBS proton therapy cohort to develop a NTCP model for radiation-induced optic neuropathy

Radiation-induced optic neuropathy (RION) is a rare, yet severe complication following radiation therapy for brain, head and neck or skull-base tumors. While several risk factors such as age, metabolic syndrome and delivered dose have been identified, we aimed at expanding the understanding of the mechanisms of interplay regarding dosimetry and patient variables leading to the onset of RION with a focus on proton therapy.

Source: International Journal of Radiation Oncology * Biology * Physics - January 5, 2021 Category: Radiology Authors: A. K öthe, P. van Luijk, S. Safai, M. Kountouri, A.J. Lomax, D.C. Weber, G. Fattori Tags: Physics Contribution Source Type: research