HIV-1 Accessory Proteins: Which one is Potentially Effective in Diagnosis and Vaccine Development?

CONCLUSION: Generally, among accessory proteins, Nef, Vpu and Vif antigens were potentially more suitable vaccine antigen candidates than Vpr antigen. Human antibodies against all these proteins were higher in HIV-1 different groups than healthy group. Among them, Vpu was known as a potent antigen in diagnosis of treated from untreated individuals. The potency of accessory proteins as an antigen candidate in an animal model and a human cohort study are underway.
PMID: 33390106 [PubMed - as supplied by publisher]

Source: Protein and Peptide Letters - December 31, 2020 Category: Biochemistry Authors: Milani A, Baesi K, Agi E, Marouf G, Ahmadi M, Bolhassani A Tags: Protein Pept Lett Source Type: research