High-dose pre-endoscopic intravenous proton pump inhibitors in upper gastrointestinal bleeding: Utility or futility?

We read with interest the article by Marmo and colleagues “Pre-endoscopic intravenous proton pump inhibitors therapy for upper gastrointestinal bleeding: a prospective, multicentre study” [1] and wish to make comments. The study, which enrolled a large number of patients [2,566 overall, 1,792 (69.8%) treated with pre-endoscopic proton pump inhibitors ( PPI)] failed to detect a significant role of such therapy in decreasing prevalence of high-risk stigmata (HRS) and need for endoscopic treatment. The issue is debated.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research