Rapid Implementation of Model-Based Dosing Recommendations During the Coronavirus Disease 2019 Pandemic —Reply

In Reply We would like to thank de Wildt and colleagues for their thoughtful commentary pertaining to our recently published article. We agree with the authors, who stressed the importance of translating these model-based dosing regimens toward clinical practice. Additionally, we would like to highlight the critical urgency for prospective randomized clinical trials evaluating the pharmacokinetics, safety, and efficacy of investigational treatments for coronavirus disease 2019 (COVID-19) in children. Such clinical investigations are essential to bridge the gap between simulation-based analyses and clinical practice.

Source: JAMA Pediatrics - January 4, 2021 Category: Pediatrics Source Type: research