Return-to-Sport Review for Current Cartilage Treatments

This article will focus on the most common current knee cartilage treatments including microfracture, autologous chondrocyte implantation, osteochondral autograft transplant, and osteochondral allograft transplantation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Special Focus Section Source Type: research

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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01096-wNme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
We describe a comprehensive multidisciplinary plan to reduce opioid use/abuse across the five phases of the surgical experience for all surgical cases and evidence of success.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Health Services Research Source Type: research
Authors: Carty CL, Noonan C, Muller C, Saner D, Reiman EM, Buchwald D, Bell RA, Nelson LA Abstract The burden of Alzheimer's disease and related dementias (ADRD) has increased substantially in the United States, particularly in health disparity populations. Little is known about the epidemiology of ADRD in American Indian (AI) adults, although they have a high prevalence of ADRD risk factors including hypertension, diabetes, obesity, and smoking. Using electronic health records from a large health care organization during 2016-18, we describe characteristics of AI patients aged ≥55 years with and without an ADRD...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Abstract Srchomology-2-domain-containing PTP 2 (SHP2) is a nonreceptor phosphatase encoded by the PTPN11 gene. Over expression of SHP2 is associated with various human diseases, such as Noonan syndrome, LEOPARD syndrome, and cancers. To overcome the shortcomings of existing orthosteric inhibitors, novel inhibitors targeting the allosteric site of SHP2 with high selectivity and low toxicity are under development. This paper reviews allosteric inhibitors of SHP2 published in patents from 2015 to 2020. The molecules are classified according to the chemical structure of the central core. SHP2 has long been considered ...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Ras family proteins play an essential role in several cellular functions, including growth, differentiation, and survival. The mechanism of action of Ras mutants in Costello syndrome and cancers has been identified, but the contribution of Ras mutants to Noonan syndrome, a genetic disorder that prevents normal development in various parts of the body, is unknown. Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor. In response to Ras-activating cell signaling, SOS autoinhibition is released and is followed by accelerative allosteric feedback autoactivation. Here, using mutagenesis-based kinetic and pulldown ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Enzymology Source Type: research
MacromoleculesDOI: 10.1021/acs.macromol.0c00422
Source: Macromolecules - Category: Chemistry Authors: Source Type: research
General examination – eyes and facial dysmorphism Clinically examination is guided by the symptoms. Unless the history is not correlated with findings, important diagnostic possibilities may be missed. Clinical examination starts off with a focused general examination followed by a detailed examination of the cardiovascular system. Relevant points in other systems like basal crepitations, hepatosplenomegaly and neurological deficits should be looked for. Examination strategy should be fitting to the clinical situation. When a patient presents to the emergency room, it should be a short but focused examination to perm...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: HBC Source Type: blogs
The MW CTR-IN grant is a U-54 Institutional Development Award (IDeA) funded by the NIH / NIGMS to increase and enhance research capacity. The CTR-IN Program (ctrin.unlv.edu) is only one of 11 clinical and translational research centers funded by NIGMS in the US. The CTR-IN involves a partnership with the 13 major public universities in the MW region (i.e., Nevada, New Mexico, Wyoming, Montana, Idaho, Alaska and Hawaii) that covers 1/3rd of the US land mass and almost 1/3rd of all IDeA states. Of the 13 CTR-IN partner public universities, only 4 have schools of medicine (SOM).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
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Source: Teaching and Learning in Medicine - Category: Universities & Medical Training Authors: Source Type: research
This study also shows that GMs' lived experiences seeking medical care were instrumental in their ability to note gaps, which provides valuable insight for other institutions attempting to improve students' GM clinical skills. Further, GM SPs' perspectives are valuable to provide a rationale and guidance to other schools implementing gender-affirming education. Efforts to create and implement gender-affirming care curriculum should include GMs in order to build partnerships and prioritize the voices and agency of GMs. PMID: 32894026 [PubMed - as supplied by publisher]
Source: Teaching and Learning in Medicine - Category: Universities & Medical Training Authors: Tags: Teach Learn Med Source Type: research
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