Risk of ischaemic stroke according to pattern of atrial fibrillation: analysis of 6563 aspirin-treated patients in ACTIVE-A and AVERROES

Aims The pattern of atrial fibrillation (AF) occurrence—paroxysmal, persistent, or permanent—is associated with progressive stages of atrial dysfunction and structural changes and may therefore be associated with progressively higher stroke risk. However, previous studies have not consistently shown AF pattern to predict stroke but have been hampered by methodological shortcomings of low power, variable event ascertainment, and variable anticoagulant use. Methods and results We analysed the rates of stroke and systemic embolism in 6563 aspirin-treated patients with AF from the ACTIVE-A/AVERROES databases. There was thorough searching for events and adjudication. Multivariable analyses were performed with the adjustment for known risk factors for stroke. Mean age of patients with paroxysmal, persistent, and permanent AF was 69.0 ± 9.9, 68.6 ± 10.2, and 71.9 ± 9.8 years (P
Source: European Heart Journal - Category: Cardiology Authors: Tags: Atrial fibrillation Source Type: research

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Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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