D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus.

CONCLUSION: D-Ser inhibits the attachment and biofilm formation of MRSA by reducing the expression of the related genes. Also, the administration of D-Ser reduces the severity of catheter infection in the mouse model. Therefore, D-Ser may be a promising therapeutic option for MRSA as well as E. coli infection.
PMID: 33385805 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - December 28, 2020 Category: Biochemistry Authors: Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T Tags: Biochem Biophys Res Commun Source Type: research