FVII gene R353Q polymorphism and coronary heart disease: a meta-analysis including 3258 subjects

AbstractThe coagulation factor VII (FVII) gene R353Q polymorphism is suggested to be relevant to the coronary heart disease (CHD) susceptibility. However, the results of separate studies are not consistent with one another. A meta-analysis including 3258 participants from nine studies was conducted to investigate the relationship between theFVII gene R353Q polymorphism and the CHD in the Chinese population. The fixed-effect models were used to assess the pooled odds ratios (ORs) and their corresponding 95% confidence intervals. A significant association was observed between theFVII gene R353Q polymorphism and the CHD in the Chinese population under allelic (OR 1.34, 95% CI 1.10 –1.65,P = 0.004), dominant (OR 0.68, 95% CI 0.55–0.85,P = 0.0006), and heterozygous (OR 0.68, 95% CI 0.55–0.85,P = 0.0007) genetic models. TheFVII gene R353Q polymorphism was significantly correlated with the CHD susceptibility in the Chinese population. Persons with the R allele of theFVII gene R353Q polymorphism might have greater CHD risk than others.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research