Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats

ConclusionLevobupivacaine is rapidly absorbed following IP administration, but its maximum plasma concentration within 2  h following IP administration is no statistical difference as that following SC administration. On the other hand, when levobupivacaine is given subcutaneously,Tmax can exceed 1  h, so we need to be aware of local anesthetic toxicity during this period.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research