Dynamic changes in circulating PD-1+CD8+ T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer

The predictive value of immune monitoring with circulating CD8+ T lymphocytes for treatment response to programmed cell death protein 1 (PD-1) inhibitors has not been explored in non-small-cell lung cancer (NSCLC), prompting us to investigate whether dynamic changes in PD-1+CD8+ T lymphocytes have predictive value for durable clinical benefit (DCB) and survival after PD-1 blockade.

Source: European Journal of Cancer - December 7, 2020 Category: Cancer & Oncology Authors: Chang Gon Kim, Min Hee Hong, Kyung Hwan Kim, In-Ho Seo, Beung-Chul Ahn, Kyoung-Ho Pyo, Chun-Bong Synn, Hong In Yoon, Hyo Sup Shim, Yong Il Lee, Seong Jin Choi, Yun Jeong Lee, Ellen Janine Kim, Youngun Kim, Jeong-Eun Kwak, Jaehyung Jung, Su-Hyung Park, Soo Tags: Original Research Source Type: research